ID   ATG1_ASPNC              Reviewed;        1007 AA.
AC   A2QIL5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   25-NOV-2008, entry version 16.
DE   RecName: Full=Serine/threonine-protein kinase atg1;
DE            EC=2.7.11.1;
DE   AltName: Full=Autophagy-related protein 1;
GN   Name=atg1; ORFNames=An04g03950;
OS   Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae;
OC   mitosporic Trichocomaceae; Aspergillus.
OX   NCBI_TaxID=425011;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G.,
RA   Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K.,
RA   Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M.,
RA   Breestraat S., Caddick M.X., Contreras R., Cornell M., Coutinho P.M.,
RA   Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M.,
RA   van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S.,
RA   Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T.,
RA   Henrissat B., Herweijer M., van den Hombergh J.P.T.W.,
RA   van den Hondel C.A.M.J.J., van der Heijden R.T.J.M.,
RA   van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P.,
RA   van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C.,
RA   Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G.,
RA   Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U.,
RA   Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J.,
RA   Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B.,
RA   Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory
RT   Aspergillus niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
CC   -!- FUNCTION: Serine/threonine protein kinase probably involved in the
CC       cytoplasm to vacuole transport (Cvt) and in autophagy, where it
CC       may be required for the formation of autophagosomes (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr
CC       protein kinase family. APG1/unc-51/ULK1 subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
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DR   EMBL; AM270075; CAK38659.1; -; Genomic_DNA.
DR   RefSeq; XP_001401761.1; -.
DR   GeneID; 4990801; -.
DR   KEGG; ang:An04g03950; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_bd_CS.
DR   InterPro; IPR017442; Se/Thr_pkinase-rel.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   InterPro; IPR002290; Ser_thr_pkinase.
DR   Pfam; PF00069; Pkinase; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Autophagy; Complete proteome; Cytoplasm; Kinase;
KW   Nucleotide-binding; Protein transport;
KW   Serine/threonine-protein kinase; Transferase; Transport.
FT   CHAIN         1   1007       Serine/threonine-protein kinase atg1.
FT                                /FTId=PRO_0000317788.
FT   DOMAIN       30    336       Protein kinase.
FT   NP_BIND      36     44       ATP (By similarity).
FT   ACT_SITE    174    174       Proton acceptor (By similarity).
FT   BINDING      59     59       ATP (By similarity).
SQ   SEQUENCE   1007 AA;  108897 MW;  D15EEE57D480DAFD CRC64;
     MGLFHHSTLF LPLLRRSNEG PHGEMPIGHY TRLSEIGRGS FAVVYKGVHT RSRTYVAIKS
     VTMTKLSRKL KENLASEISI LKQLHHPHIV ALLDCHDTTS NIHLVMEFCA LGDLSHFIKG
     RNTLQDSPYT RELIAKYPNP GEGAGLNEVI VRHFLKQLSS ALRFLRDRDL IHRDIKPQNL
     LLCPAPSSYR SGAADVVPFK SSEDSFSPKT GLESLPMLKL ADFGFARSLP ATSLAETLCG
     SPLYMAPEIL RYEKYDAKAD LWSVGTVLYE MVVGRAPFRA VNHIELIKKI EQNKDQISFP
     SKNRVSEDIR ELIRGLLKQH PMDRMNFDVY FAHKVLTEPI PGLVADDAPL GRSPADPTPR
     PGSGSRRSTP VQMKRENALS GGVRDEPATY PAAQRAMTQS PRPETPSTPM RRTGSAGTPH
     AAPNEPTPPA SHPTRPSPVS LATAPGRQEH VDRPPTTTVV EQQRRRTASS GVPQVDKPVE
     KAKDEKEHAA QEVAFERDYV LVEKRAVEMN AFADELAYNP RMQGGQAGAV SRRSGAAPGT
     PPAGGSSPHA SPSKAMQIIS GRSRADSAHV RQNSYDRRYG QSPTSATSAI SKALNMASGR
     LFGMSFSPPL TITKGGRSPP LAYNPFPAYP SAQTSLIVHA DGGKPGANLD EDSKTVHDLE
     ECATRSDVVY GFAEVKYKQL IPLAPSAATG YPGDPGSDAV DSADGGLTVD AIVTLSEEAL
     VLYVKALSLL AKSMDIARVW WTRKSRGDTL SRADTGSTVA GNRINNVVQW VRNRFNEVLE
     KAEFVRLKLV EAQKRLPSDH PSHPSNLSVG SSLGSGTSAD VVVSPDVTAE KLMYERALEM
     SRVAAINEIT GEDLAGCEIS YVTAIRMLEA ILDDVEVSRP GQSGGADRAD ARRDNEDGGQ
     NEPQAVILAK SANAWHSDIE NPESPGVAPE EAGAAVESVH APVQWTGQNA AVESGASLPC
     SGSHAAEIRT LTVRSMQDHA HFAPLLFSIF ISSYSSSISC PSSCGHC
//