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UniProtKB/Swiss-Prot entry A1TP96

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MDH_ACIAC
Primary accession number A1TP96
Secondary accession numbers None
Integrated into Swiss-Prot on July 10, 2007
Sequence was last modified on February 6, 2007 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 16)
Name and origin of the protein
Protein name Malate dehydrogenase
Synonym EC 1.1.1.37
Gene name
Name: mdh
OrderedLocusNames: Aave_2206
From
Acidovorax avenae subsp. citrulli (strain AAC00-1) [TaxID: 397945] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Comamonadaceae; Acidovorax.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.;
"Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1.";
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000512; ABM32784.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_970558.1; -.
3D structure databases
SMR A1TP96; 3-328.
ModBase A1TP96.
Ontologies
GO
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0030060; Molecular function: L-malate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0006096; Biological process: glycolysis (inferred from electronic annotation from InterPro).
GO:0006108; Biological process: malate metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01517; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR001252; Malate_DHase_AS.
IPR010945; Malate_DHase_SF1.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR23382; MDH_SF1; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
ProDom PD003052; Mal_dehydrog; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01759; MalateDH-SF1; 1.
PROSITE PS00068; MDH; FALSE_NEG.
ProtoNet A1TP96.
Genome annotation databases
GeneID 4668190; -.
GenomeReviews CP000512_GR; Aave_2206.
KEGG aav:Aave_2206; -.
NMPDR fig|397945.5.peg.1904; -.
CMR A1TP96; Aave_2206.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   328  327     Malate dehydrogenase. PRO_0000294370
NP_BIND   12    18  7     NAD (By similarity). 
NP_BIND   132   134  3     NAD (By similarity). 
ACT_SITE   190   190        Proton acceptor (By similarity). 
BINDING   95    95        Substrate (By similarity). 
BINDING   101   101        Substrate (By similarity). 
BINDING   108   108        NAD (By similarity). 
BINDING   115   115        NAD (By similarity). 
BINDING   134   134        Substrate (By similarity). 
BINDING   165   165        Substrate (By similarity). 
Sequence information
Length: 328 AA [This is the length of the unprocessed precursor] Molecular weight: 34977 Da [This is the MW of the unprocessed precursor] CRC64: A6D2BC04ED5AD6E2 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSKKPVRVAV TGAAGQIGYA LLFRIASGEM LGKDQPVILQ LLEIPDEKAQ KALKGVMMEL 

        70         80         90        100        110        120 
EDCAFPLLAG MEAHSDPMTA FKDTDYALLV GARPRGPGME RADLLAANAQ IFTAQGKALN 

       130        140        150        160        170        180 
AVASRNVKVL VVGNPANTNA YIAMKSAPDL PAKNFTAMLR LDHNRAASQI AAKTGGKVGE 

       190        200        210        220        230        240 
IEKLTVWGNH SPTMYADYRF ATIGGKSVKD AINDQVWNAD VFLPTVGKRG AAIIEARGLS 

       250        260        270        280        290        300 
SAASAANAAI DHMRDWALGS NGKWVTMGVP SKGEYGIPEG IVFGFPVITE NGEYKIVEGL 

       310        320 
EIDAFSQERI NKTLAELQGE QDGVKHLL
A1TP96 in FASTA format

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