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UniProtKB/Swiss-Prot entry A1D4H0


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MCR1_NEOFI
Primary accession number A1D4H0
Secondary accession numbers None
Integrated into Swiss-Prot on April 29, 2008
Sequence was last modified on January 23, 2007 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 17)
Name and origin of the protein
Protein name NADH-cytochrome b5 reductase 2
Synonyms EC 1.6.2.2
Mitochondrial cytochrome b reductase
Gene name
Name: mcr1
ORFNames: NFIA_020210
From
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / NRRL 181) (Aspergillus fischerianus (strain ATCC 1020 / DSM 3700 / NRRL 181)) [TaxID: 331117] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; Eurotiomycetidae; Eurotiales; Trichocomaceae; Neosartorya.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1371/journal.pgen.1000046; PubMed=18404212 [NCBI, ExPASy, EBI, Israel, Japan]
Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M., Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
"Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.";
PLoS Genet. 4:E1000046-E1000046(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
DS027688; EAW23313.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_001265210.1; -.
3D structure databases
ModBase A1D4H0.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005741; Cellular component: mitochondrial outer membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0004128; Molecular function: cytochrome-b5 reductase activity (inferred from electronic annotation from EC).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001834; Cyt_B5_reductase.
IPR001709; FPN_cyt_redctse.
IPR008333; OxRdtase_FAD-bd.
IPR001433; OxRdtase_FAD/NAD_bd.
Graphical view of domain structure.
Pfam PF00970; FAD_binding_6; 1.
PF00175; NAD_binding_1; 1.
Pfam graphical view of domain structure.
PRINTS PR00406; CYTB5RDTASE.
PR00371; FPNCR.
PROSITE PS51384; FAD_FR; 1.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
GeneID 4591841; -.
Other
ProtoNet A1D4H0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; FAD; Flavoprotein; Membrane; Mitochondrion; Mitochondrion outer membrane; NAD; Oxidoreductase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   323  323     NADH-cytochrome b5 reductase 2. PRO_0000330185
TRANSMEM   32    48  17     Potential. 
DOMAIN   72   177  106     FAD-binding FR-type. 
NP_BIND   180   215  36     FAD (By similarity). 
Sequence information
Length: 323 AA [This is the length of the unprocessed precursor] Molecular weight: 36231 Da [This is the MW of the unprocessed precursor] CRC64: A99290424B1703E9 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MFARQSLRFA QPLKQGFRKY STEAPSKGKS SLAPIYVAVG LTGLGVGLYR YNSASAEAPP 

        70         80         90        100        110        120 
AERPKVFTGG DQGWVDLKLA QIENLSPNTK RLRFEFPDKE AVSGLHVASA LLTKFKPHGA 

       130        140        150        160        170        180 
EKPVIRPYTP VSDEEQPGYL DLVVKVYPNG PMSEHLHSMN VDQRLEFKGP IPKYPWEANK 

       190        200        210        220        230        240 
HKHICLIAGG TGITPMYQLA RKIFKDPEDQ TKVTLVFGNV REEDILLKKE LQELENTYPR 

       250        260        270        280        290        300 
RFRAFYVLDH PPKEWTGGKG YITKELLKTV LPEPKEENIK IFVCGPPGMY KSISGPKVSP 

       310        320 
KDQGELTGIL AELGYSKDQV FKF 

A1D4H0 in FASTA format

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