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NiceZyme View of ENZYME: EC 1.2.1.8

Official Name
Betaine-aldehyde dehydrogenase.
Alternative Name(s)
BADH.
Betaine aldehyde dehydrogenase.
Betaine aldehyde oxidase.
Reaction catalysed
Betaine aldehyde + NAD(+) + H(2)O <=> betaine + NADH
Comment(s)
  • In many bacteria, plants and animals, the osmoprotectant betaine is synthesized in two steps: (1) choline to betaine aldehyde and (2) betaine aldehyde to betaine.
  • This enzyme is involved in the second step and appears to be the same in plants, animals and bacteria.
  • In contrast, different enzymes are involved in the first reaction.
  • In plants, this reaction is catalyzed by EC 1.14.15.7, whereas in animals and many bacteria, it is catalyzed by either membrane-bound choline dehydrogenase (EC 1.1.99.1) or soluble choline oxidase (EC 1.1.3.17).
  • In some bacteria, betaine is synthesized from glycine through the actions of EC 2.1.1.156 and EC 2.1.1.157.
Cross-references
Biochemical Pathways; map number(s)B8
PROSITEPDOC00068
BRENDA1.2.1.8
PUMA21.2.1.8
PRIAM enzyme-specific profiles1.2.1.8
KEGG Ligand Database for Enzyme Nomenclature1.2.1.8
IUBMB Enzyme Nomenclature1.2.1.8
IntEnz1.2.1.8
MEDLINEFind literature relating to 1.2.1.8
MetaCyc1.2.1.8
UniProtKB/Swiss-Prot
Q9S795, BADH1_ARATH;  Q9STS1, BADH2_ARATH;  O04895, BADH_AMAHP;  
P42757, BADH_ATRHO;  P28237, BADH_BETVU;  P56533, BADH_GADCA;  
Q40024, BADH_HORVU;  O24174, BADH_ORYSJ;  O59808, BADH_SCHPO;  
P17202, BADH_SPIOL;  P54222, BETB1_RHIME;  Q92YD2, BETB2_RHIME;  
Q6FDF8, BETB_ACIAD;  Q8UH56, BETB_AGRT5;  P71016, BETB_BACSU;  
Q2YMP8, BETB_BRUA2;  Q57EI0, BETB_BRUAB;  A9M9H7, BETB_BRUC2;  
Q8YFY0, BETB_BRUME;  A5VPA5, BETB_BRUO2;  B0CKN3, BETB_BRUSI;  
Q8G1Z9, BETB_BRUSU;  Q1BQE1, BETB_BURCA;  A0B2F6, BETB_BURCH;  
Q0B712, BETB_BURCM;  A3MEC6, BETB_BURM7;  A2RWD6, BETB_BURM9;  
Q62CH7, BETB_BURMA;  A1UVS4, BETB_BURMS;  A3P6B0, BETB_BURP0;  
Q3JLL8, BETB_BURP1;  A3NKP8, BETB_BURP6;  Q63KK8, BETB_BURPS;  
Q39A43, BETB_BURS3;  A4JJG5, BETB_BURVG;  Q13NG6, BETB_BURXL;  
Q9L4K1, BETB_CHRSD;  A7ZI51, BETB_ECO24;  Q7AH91, BETB_ECO57;  
A7ZWV5, BETB_ECOHS;  Q0TKW0, BETB_ECOL5;  Q8FKI8, BETB_ECOL6;  
B1J0W5, BETB_ECOLC;  P17445, BETB_ECOLI;  Q6D6E0, BETB_ERWCT;  
A6W2P7, BETB_MARMS;  A6X2G8, BETB_OCHA4;  Q48CM6, BETB_PSE14;  
A6VEI4, BETB_PSEA7;  Q02DY9, BETB_PSEAB;  Q9HTJ1, BETB_PSEAE;  
Q1IG69, BETB_PSEE4;  Q4K4K8, BETB_PSEF5;  A4XPI6, BETB_PSEMY;  
A5WA96, BETB_PSEP1;  Q3K5H4, BETB_PSEPF;  B0KN18, BETB_PSEPG;  
Q88CW7, BETB_PSEPK;  Q88AE9, BETB_PSESM;  Q4ZM62, BETB_PSEU2;  
A4VKC2, BETB_PSEU5;  Q2KB42, BETB_RHIEC;  Q1MJU3, BETB_RHIL3;  
Q985M6, BETB_RHILO;  A3PI00, BETB_RHOS1;  Q3J4E9, BETB_RHOS4;  
A4WUY6, BETB_RHOS5;  A8GBX8, BETB_SERP5;  Q0T7M9, BETB_SHIF8;  
A6U6Y9, BETB_SINMW;  A7N2Q0, BETB_VIBHB;  Q87H52, BETB_VIBPA;  
Q8D3K3, BETB_VIBVU;  Q7MF13, BETB_VIBVY;  Q8PPG7, BETB_XANAC;  
Q3BXK7, BETB_XANC5;  Q4UYN4, BETB_XANC8;  Q8P5D8, BETB_XANCP;  
A7FKL5, BETB_YERP3;  Q1C931, BETB_YERPA;  Q8ZGV9, BETB_YERPE;  
Q1CFR8, BETB_YERPN;  A4TNP1, BETB_YERPP;  Q66D53, BETB_YERPS;  

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