| Official Name |
|---|
| [Histone H3]-lysine-36 demethylase.
|
| Alternative Name(s) |
|---|
| H3-K36-specific demethylase. |
| Histone demethylase. |
| Histone-lysine (H3-K36) demethylase. |
| JHDM1A. |
| JmjC domain-containing histone demethylase 1A. |
| Reaction catalysed |
|---|
- Protein N(6),N(6)-dimethyl-L-lysine + 2-oxoglutarate + O(2) <=> protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO(2)
- Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O(2) <=> protein L-lysine + succinate + formaldehyde + CO(2)
|
| Cofactor(s) |
|---|
| Fe(2+).
|
| Comment(s) |
|---|
- Of the seven potential methylation sites in histones H3 (K4, K9, K27,
K36, K79) and H4 (K20, R3) from HeLa cells, the enzyme is specific
for Lys-36.
- Lysine residues exist in three methylation states (mono-, di- and
trimethylated).
- The enzyme preferentially demethylates the dimethyl form of Lys-36
(K36me2), which is its natural substrate, to form the monomethyl and
unmethylated forms of Lys-36.
- It can also demethylate the monomethyl- but not the trimethyl form of
Lys-36.
|
| Cross-references |
|---|
| BRENDA | 1.14.11.27 |
| PUMA2 | 1.14.11.27 |
| PRIAM enzyme-specific profiles | 1.14.11.27 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.11.27 |
| IUBMB Enzyme Nomenclature | 1.14.11.27 |
| IntEnz | 1.14.11.27 |
| MEDLINE | Find literature relating to 1.14.11.27 |
| MetaCyc | 1.14.11.27 |
| UniProtKB/Swiss-Prot |
| Q9Y2K7, JHD1A_HUMAN; | P59997, JHD1A_MOUSE; | Q5U263, JHD1A_XENTR; |
| Q8NHM5, JHD1B_HUMAN; | Q6P1G2, JHD1B_MOUSE; | Q640I9, JHD1B_XENLA; |
| Q75AL5, JHD1_ASHGO; | Q4WHB7, JHD1_ASPFU; | Q60V67, JHD1_CAEBR; |
| Q95Q98, JHD1_CAEEL; | Q5A847, JHD1_CANAL; | Q6FPL6, JHD1_CANGA; |
| Q55NZ6, JHD1_CRYNE; | Q6BXJ4, JHD1_DEBHA; | Q9VHH9, JHD1_DROME; |
| Q5AW75, JHD1_EMENI; | Q6CIC9, JHD1_KLULA; | O94603, JHD1_SCHPO; |
| Q4P5U1, JHD1_USTMA; | Q6C423, JHD1_YARLI; | P40034, JHD1_YEAST; |
|
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