| Official Name |
|---|
| o-aminophenol oxidase.
|
| Alternative Name(s) |
|---|
| Isophenoxazine synthase. |
| Reaction catalysed |
|---|
| 2 2-aminophenol + O(2) + oxidant <=> 2-aminophenoxazin-3-one + 2 H(2)O + reduced oxidant |
| Cofactor(s) |
|---|
| Copper or manganese; Flavoprotein.
|
| Comment(s) |
|---|
- While the enzyme from the plant Tecoma stans is activated by Mn(2+),
that from the bacterium Streptomyces griseus (GriF) requires Cu(2+)
for maximal activity.
- Two molecules of the product 6-iminocyclohexa-2,4-dienone (i.e. 1,2-
benzoquinone monoimine) spontaneously condense with oxidation to
yield 2-aminophenoxazin-3-one.
- 3-amino-4-hydroxybenzaldehyde, which has a -CHO group at the para-
position with respect to the hydroxy group of 2-aminophenol,
was found to be the best substrate for GriF.
|
| Cross-references |
|---|
| BRENDA | 1.10.3.4 |
| PUMA2 | 1.10.3.4 |
| PRIAM enzyme-specific profiles | 1.10.3.4 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.10.3.4 |
| IUBMB Enzyme Nomenclature | 1.10.3.4 |
| IntEnz | 1.10.3.4 |
| MEDLINE | Find literature relating to 1.10.3.4 |
| MetaCyc | 1.10.3.4 |
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