Expasy logo

ENZYME

ENZYME entry: EC 3.4.21.74

Accepted Name
venombin A
Reaction catalysed
Selective cleavage of Arg-|-Xaa bond in fibrinogen, to form fibrin, and release fibrinopeptide A. The specificity of further degradation of fibrinogen varies with species origin of the enzyme
Comment(s)
  • A somewhat thrombin-like enzyme from venoms of snakes of the viper/rattlesnake group.
  • Species variants of the enzyme include ancrod from Agkistrodon rhodostoma (Malayan pit viper), batroxobin from Bothrops atrox (South American pit viper) and crotalase from Crotalus adamanteus (Eastern diamondback rattlesnake).
  • Does not require activation by calcium.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.21.28, EC 3.4.21.29 and EC 3.4.21.30.
Cross-references
BRENDA3.4.21.74
EC2PDB3.4.21.74
ExplorEnz3.4.21.74
PRIAM enzyme-specific profiles3.4.21.74
KEGG Ligand Database for Enzyme Nomenclature3.4.21.74
IUBMB Enzyme Nomenclature3.4.21.74
IntEnz3.4.21.74
MEDLINEFind literature relating to 3.4.21.74
MetaCyc3.4.21.74
Rhea expert-curated reactions3.4.21.74
UniProtKB/Swiss-Prot
P05620, VSP1_PROFLP81661, VSPA_BOTJAF8S114, VSPCR_CROAD
P26324, VSPF1_CALRHP47797, VSPF2_CALRHP04971, VSPF_BOTAT
Q9PS28, VSPF_CERCEQ9PRP4, VSPF_LACMRP33589, VSPF_LACMU
P0DJ86, VSPL_BOTLC

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-