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ENZYME

ENZYME entry: EC 3.4.17.13

Accepted Name
muramoyltetrapeptide carboxypeptidase
Alternative Name(s)
carboxypeptidase IIW
Reaction catalysed
H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine <=> D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl
Comment(s)
  • Variants are known from various microorganisms.
  • Involved in peptidoglycan synthesis, catalyzing both decarboxylation and transpeptidation.
  • Stimulated by divalent cations such as magnesium and calcium, but not zinc.
  • Inhibited by thiol-blocking reagents, but unaffected by penicillin.
Cross-references
BRENDA3.4.17.13
EC2PDB3.4.17.13
ExplorEnz3.4.17.13
PRIAM enzyme-specific profiles3.4.17.13
KEGG Ligand Database for Enzyme Nomenclature3.4.17.13
IUBMB Enzyme Nomenclature3.4.17.13
IntEnz3.4.17.13
MEDLINEFind literature relating to 3.4.17.13
MetaCyc3.4.17.13
Rhea expert-curated reactions3.4.17.13
UniProtKB/Swiss-Prot
Q8XDJ8, LDCA_ECO57P59238, LDCA_ECOL6P76008, LDCA_ECOLI
Q9HTZ1, LDC_PSEAEP0AFV6, MEPS_ECO57P0AFV5, MEPS_ECOL6
P0AFV4, MEPS_ECOLIP0AFV7, MEPS_SHIFLQ9VYX7, PGPSA_DROME

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