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ENZYME

ENZYME entry: EC 2.4.1.135

Accepted Name
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
Alternative Name(s)
glucuronosyltransferase I
uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase
Reaction catalysed
3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
Comment(s)
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates).
Cross-references
BRENDA2.4.1.135
EC2PDB2.4.1.135
ExplorEnz2.4.1.135
PRIAM enzyme-specific profiles2.4.1.135
KEGG Ligand Database for Enzyme Nomenclature2.4.1.135
IUBMB Enzyme Nomenclature2.4.1.135
IntEnz2.4.1.135
MEDLINEFind literature relating to 2.4.1.135
MetaCyc2.4.1.135
Rhea expert-curated reactions2.4.1.135
UniProtKB/Swiss-Prot
Q9VTG7, B3G2P_DROMEQ9VLA1, B3G2S_DROMEQ5CB03, B3GA1_CANLF
Q9P2W7, B3GA1_HUMANQ9CW73, B3GA1_MOUSEQ5CB04, B3GA1_PANTR
O35789, B3GA1_RATQ5CAZ6, B3GA2_CANLFQ9NPZ5, B3GA2_HUMAN
P59270, B3GA2_MOUSEQ9Z137, B3GA2_RATQ9WU47, B3GA3_CRIGR
O94766, B3GA3_HUMANP58158, B3GA3_MOUSEO97422, B3GI_DROME
Q09363, SQV8_CAEEL

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
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