Expasy logo

ENZYME

ENZYME entry: EC 1.14.18.2

Accepted Name
CMP-N-acetylneuraminate monooxygenase
Alternative Name(s)
CMP-N-acetylneuraminate hydroxylase
CMP-N-acetylneuraminic acid hydroxylase
CMP-Neu5Ac hydroxylase
cytidine monophosphoacetylneuraminate monooxygenase
Reaction catalysed
CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O
Comment(s)
  • The ferricytochrome b5 produced is reduced by NADH and EC 1.6.2.2.
  • The enzyme can be activated by Fe(2+) or Fe(3+).
  • Formerly EC 1.14.13.45.
Cross-references
BRENDA1.14.18.2
EC2PDB1.14.18.2
ExplorEnz1.14.18.2
PRIAM enzyme-specific profiles1.14.18.2
KEGG Ligand Database for Enzyme Nomenclature1.14.18.2
IUBMB Enzyme Nomenclature1.14.18.2
IntEnz1.14.18.2
MEDLINEFind literature relating to 1.14.18.2
MetaCyc1.14.18.2
Rhea expert-curated reactions1.14.18.2
UniProtKB/Swiss-Prot
Q95V11, CMAH_ASTRUQ9WV23, CMAH_CRIGRQ6GML1, CMAH_DANRE
Q8MJC8, CMAH_GORGOQ9TUJ2, CMAH_MACMUQ61419, CMAH_MOUSE
Q8MJD0, CMAH_PANPAO97598, CMAH_PANTRO19074, CMAH_PIG
Q8MJC6, CMAH_PONPYQ8AVF5, CMAH_XENLA

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.18.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-